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Tuesday, August 11, 2020 | History

3 edition of Lipid metabolism and membrane functions of the mammary gland found in the catalog.

Lipid metabolism and membrane functions of the mammary gland

S. Patton

Lipid metabolism and membrane functions of the mammary gland

by S. Patton

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  • 11 Currently reading

Published by Pergamon in Oxford .
Written in English


Edition Notes

Statementby S. Patton [and] R.G. Jensen.
SeriesProgress in the chemistry of fats and other lipids -- 14/4
ContributionsJensen, Robert G.
ID Numbers
Open LibraryOL22706272M
ISBN 100080182224
OCLC/WorldCa9060839

Of these, 23 transporters and enzymes were related to lipid synthesis and secretion in mammary gland and their functions are discussed in detail. The identification of these intracellular transporters and enzymes in milk provides a possibility of using milk itself to study lipid synthesis and secretion pathways. the mouse mammary gland offers an outstanding model system for examining developmental regulation of metabolic processes. Pregnancy in this species lasts ∼19 days including an intensive proliferative phase followed by a differentiation phase marked by an increase in milk protein gene expression, lipid droplet formation, and stromal adaptations (42, 43).

  After ingested fats (lipids) are cleaved by enzymes, lipids are absorbed in the small intestine and transported via the lymphatic system into the bloodstream. During this transport process, lipids are bound to special hydrophilic lipoproteins control fat metabolism and have different proportions of bound fat as well as different functions. We have used a murine model to assess whether a low-CHO, high-unsaturated-fat diet (as unsaturated fat produces favorable effects on lipid metabolism) during pregnancy has any long-term beneficial effect on the offspring with a focus on the metabolic parameters and hepatic lipid metabolism.

  It is a component of membrane structural lipids and functions in specific cell signaling pathways (Panel on Macronutrients, ). Linoleic acid is required for the synthesis of other omega-6 fatty acids, which are important for normal epithelial cell function (specifically, maintaining the epidermal water barrier) (Panel on Macronutrients, ). A prominent effect of 17β-estradiol was the regulation of genes related to lipid metabolism. 17β-Estradiol treatment enhanced the expression of genes encoding monoacylglycerol O-acyltransferase 1, which catalyzes the formation of diacylglycerol, 30 and phosphatidylcholine transfer protein, which replenishes the plasma membrane with.


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Lipid metabolism and membrane functions of the mammary gland by S. Patton Download PDF EPUB FB2

Progress in the Chemistry of Fats and other Lipids VolPagesIN1-IN2,IN3-IN4,IN5,IN6,IN7,IN8,IN9, Lipid metabolism and membrane functions of the mammary glandCited by: Biomedical aspects of lactation: With special reference to lipid metabolism and membrane functions of the mammary gland (Pergamon international technology, engineering and social studies) [Patton, Stuart] on *FREE* shipping on qualifying offers.

Biomedical aspects of lactation: With special reference to lipid metabolism and membrane functions of the mammary gland (Pergamon Cited by: 6. Revision of Lipid metabolism and membrane functions of the mammary gland originally published in Progress in the chemistry of fats and other lipids, v.

14, pt. Description: viii, pages, 7 unnumbered leaves of plates: illustrations ; 25 cm. Series Title: Pergamon international library of science, technology, engineering, and social studies. The contralateral mammary glands were removed for analysis of lipoprotein lipase activity at the start of the perfusion.

Perfused mammary glands of normal lactating rats removed 15% of the chylomicron cholesterol and about 12% of the triglyceride infused while the tissue of hypophysectomized rats removed less than 1% of each lipid by: Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions.

In mammary glands of. Oleic and palmitic acids change membrane lipid composition. Lipogenic activity in an adipocyte cell line was found to be associated with changes in cellular phospholipid composition.

Therefore, we determined the amount and composition (weight %) of the main membrane phospholipids in mammary epithelial cells in the presence of different FFAs.

FoxA transcription factors are critical regulators of tissue development, tissue function and metabolism 4. Lipid metabolism and membrane functions of the mammary gland book In the mammary gland, FoxA1 contributes to the differentiation of luminal epithelial.

As the responsiveness of p53 to ionizing radiation increases rapidly after exposure to E and P, the transcriptional responses in the mammary gland after acute stimulation with these hormones provide a method to elucidate hormone-responsive pathways that regulate p53 function.

In these experiments mice were treated with E and P, individually. Lipid metabolism and membrane functions of the mammary gland. In R. Holman (ed.), Progress in the Chemistry of Fats and other Lipids (Vol.

XIV) Part 4. In addition, the effect of various lipids, including dietary lipids, on membrane raft structure and function will be discussed. Membrane rafts are found in all cells and are characterized by their high concentration of cholesterol, sphingolipids, and saturated fatty acids.

Prog Chem Fats Other Lipids. ;14(4) Lipid metabolism and membrane functions of the mammary gland. Patton S, Jensen RG. PMID. Human mammary neoplasia is characterized by altered lipid metabolism. For example, the expression of fatty acid synthase (named oncogene antigen, OA ) was identified as a marker for aggressive.

Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integration of PL and FA synthesis and transport processes to meet secretion demands.

DOI: /S(97) Corpus ID: Lipid metabolism in the lactating mammary gland. @article{BarberLipidMI, title={Lipid metabolism in the lactating mammary gland.}, author={M. Chiquillo Barber and Roger A. Clegg and Maureen T. Travers and Richard G. Vernon}, journal={Biochimica et biophysica acta}, year={}, volume={ }, pages={ } }.

Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell animals, these fats are obtained from food or are synthesized by the liver.

Lipogenesis is the process of synthesizing these fats. Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases; however, other studies observed faster tumour growth.

The related molecule butyrate also inhibits growth of some cancer cells and accelerates it in others. This “butyrate paradox” is thought to be due to butyrate mediating histone. Dietary lipids and metabolic syndrome. MS, also known as syndrome X, or the insulin resistance syndrome, is a combination of medical disorders comprising an array of metabolic risk factors including central obesity, dyslipidemia, hypertension, glucose intolerance, and insulin resistance[].The worldwide prevalence of MS causes lots of health problems not only in the developed.

Although important in mediating the function of various hormones, the role of SP1 in regulating milk fat formation remains unknown.

To investigate the sequence and expression information, as well as its role in modulating lipid metabolism, we cloned SP1 gene from mammary gland. Lipid Metabolism in Mammary Epithelial Cells-A Comparison of Common In-Vitro Models Bat-Chen Cohen1, Avi Shamay 2 and Nurit Argov-Argaman 1* 1The Animal Science Department, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem,Rehovot, Israel 2Ruminant Science Department, Agricultural Research Organization, Volcani Center, Bet.

Goals / Objectives Our overall goal is to better understand the role of lipid metabolism in mammary gland development and reproductive physiology. We are uniquely situated to carry out this research because of our expertise in the molecular genetics of TG synthesis enzymes and our proximity to collaborators and resources at the University of Wisconsin-Madison, including Dr.

Laura Hernandez. LACTB modulates mitochondrial lipid metabolism and changes the differentiation state of breast cancer cells, thereby negatively affecting the growth of .Mammary epithelial cells are regulated by steroid hormones, growth factors, and even microRNAs.

miRb has been found to regulate lipid metabolism in adipocytes; however, its effects on lipid metabolism in mammary epithelial cells, the cells of lipid synthesis and secretion, are as yet unknown.-sexual development and function-Metabolism and growth-Immune responses *(all of these are regulated by hormones) -pass through cell membrane stimulates milk production by mammary glands of breasts.

functions of human growth hormone. Growth of skeletal muscles-lipid metabolism-growth of skeletal tissues.